NLRP3 inflammasome has a protective effect against oxazolone-induced colitis: a possible role in ulcerative colitis
نویسندگان
چکیده
منابع مشابه
NLRP3 inflammasome has a protective effect against oxazolone-induced colitis: a possible role in ulcerative colitis
The inflammasomes induce maturation of pro-interleukin-1β (IL-1β) and pro-IL-18. We investigated roles of the NLRP3 inflammasome in the pathogenesis of ulcerative colitis (UC). After induction of oxazolone-induced colitis, a mouse UC model, colonic tissues were assayed for inflammatory mediators. Histological studies were performed on inflamed colonic tissue from mice and UC patients. Histologi...
متن کاملProtective effect of Mumiju against acetic acid-induced ulcerative colitis in rats
Objective: In this study, we elucidated the ameliorative effect of aqueous extract of leaves of Mumiju against acetic acid-induced experimental colitis in male rats. Materials and Methods: The animals were randomly divided into four groups (n=7) including I: control group, II: vehicle group (injected with 2 ml acetic acid (4%) intra rectally), III and IV: treatment groups which received Mumiju ...
متن کاملexpression levels of proinflammatory cytokines and nlrp3 inflammasome in an experimental model of oxazolone-induced colitis
il-1β and il-17a are two cytokines with strong proinflammatory activities and are now known to be involved in a number of chronic inflammatory disorders. high-mobility group box 1 (hmgb1) is a nuclear protein regulating the expression of these proinflammatory cytokines. the nlrp3 inflammasome promotes the maturation of the il-1β and its activation has been shown as a critical mechanism in the p...
متن کاملExpression Levels of Proinflammatory Cytokines and NLRP3 Inflammasome in an Experimental Model of Oxazolone-induced Colitis.
IL-1β and IL-17A are two cytokines with strong proinflammatory activities and are now known to be involved in a number of chronic inflammatory disorders. High-mobility group box 1 (HMGB1) is a nuclear protein regulating the expression of these proinflammatory cytokines. The NLRP3 inflammasome promotes the maturation of the IL-1β and its activation has been shown as a critical mechanism in the p...
متن کاملProtective Effect of Ketamine against Acetic Acid-Induced Ulcerative Colitis in Rats
Objective: Inflammatory bowel diseases (IBD), including Crohn’s disease and ulcerative colitis (UC), are chronic and recurrent disorders of the gastrointestinal tract with unknown etiology. Considering the adverse effects and incomplete efficacy of currently administered drugs, it is crucial to explore new drugs with more desirable therapeutic profiles. As non-competitive N-methylD-aspartate (N...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Scientific Reports
سال: 2016
ISSN: 2045-2322
DOI: 10.1038/srep39075